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Our science, your DNA

We are all different, and a part of this difference is as a result of our genetic profile.

Genetically, there are the differences that we all see, such as eye and hair colour, but there are also the differences we don’t see, how we metabolise nutrients for example, the way we deal with toxins, how well we react to different types of exercise – we all interact with the environment in our own unique way.

Genetically we are almost identical, but in each gene there are points of variation. The most common type of variation is a single base change at a particular position – this variation is called a Single Nucleotide Polymorphism, or SNP for short (pronounced ‘snip’).

It is in the combination of these tiny differences that we define our individuality, who we are.

But genes are not the whole picture, they don’t work alone and they don’t determine everything about us.

Genes interact with our environment – and modifying the environment modifies our “phenotype” – the way we are (e.g. a fair skinned person will only suffer from sunburn if she/he stays in the sun too long).

Because we have some control over our environment (in our case exercise and nutrition choices) we therefore can work to create the best phenotype for our lifestyle.

At DNAFit we focus our work specifically on these two realms of genetic science - Exercise Genomics & Nutrigenomics, with the aim of helping our customers train, eat and feel their best.

Learn more about the genes we test for

ACE
ACTN3
AGT
IL-6
TRHR
ADRB2
ADRB2
ADRB3
PPARA
PPARGC1A
COL1A1
COL5A1
GSTT1
APOA2
FABP2
FTO
PPARG
TCF7L2
VDR
CRP
VEGF
GDF5
GSTM1

How do you know the genes in your DNA test provide real, actionable information?

We use only the most researched genes for our reports, and each of our genes pass a strict inclusion protocol before we consider them for use. This is what sets us apart from other companies.

Genetics is only one part of the picture, so we never overstate the application of genetics in the real world. The value comes from understanding your genetic profile in conjunction with your goals, lifestyle and environment – the whole picture.

How we select the genes

1. Search

We search through all the published literature from many hundreds of scientific studies for candidate genes.

2. Sort

We then sort the candidate papers and rank according to applicable relevance, looking for a good sample size, a reputable journal and evidence of gene x environment interaction.

3. Establish

Our Scientific Advisory Board establish the scientific validity of the gene x environment interaction and its link to to personal fitness and nutrition utility.

4. Include

The board then present their findings to include in the DNAFit reports only once the evidence is clear regarding an easily modifiable gene x environment interaction with a positive outcome, and that this effect is shown in multiple studies.

The studies behind the science

We use hundreds of studies to bring you the genetic information in the DNAFit report. Take a look below at some of our reference papers to give you an insight into the world of exercise and nutrigenomics.

Get your guide!

Receive our FREE 14-day guide, direct to your inbox, on how genetics impact every aspect of fitness and nutrition.