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3473 Posted 277 Days Ago in: Genetics, Nutrition
Sodium is a key component of many foods regularly consumed by people on a daily basis and although health recommendations often advise otherwise, there is still not enough done to stop people from adding excessive amount of salt to their foods. A major problem with this is that sodium is contained in many regular food products, added to increase the flavor and taste of foods that would otherwise possibly be too bland. But although we all regularly consume sodium every single day, the question is whether or not turning to a low sodium diet is healthy for people. Research has shown that 1.65 million deaths from cardiovascular causes that occurred in 2010 were attributed to sodium consumption above a reference level of 2.0 g per day.
3438 Posted 330 Days Ago in: Training, Genetics, Nutrition
The 20,000+ genes that make up your genome hold countless clues to understanding the fundamental processes of human life. Ever since the completion of the Human Genome Project, our knowledge of how we are made has developed at an unprecedented rate. In our case, it opened a new realm of information about your individual fitness and nutrition needs, easily accessible from one little mouth swab.
3432 Posted 353 Days Ago in: Genetics
We all have people who we know: friends, family, acquaintances, and work colleagues who all have distinctly different tastes when it comes to food. Some like it hot, while othersâ€¦not so much. Others devour sugary treats in the blink of an eye, and without flinching, while other people wince at the sight of a rich quadruple chocolate dessert; politely declining the offer. The list goes on, but other than getting a â€śtasteâ€ť for certain foods, are there other factors at play?
3418 Posted 393 Days Ago in: Training, Nutrition
When youâ€™ve finally settled into your routine and are training regularly, youâ€™ll start hearing about supplements you can take to increase your performance, recovery, and response to various types of exercise. The industry has exploded to the point where it is worth billions, and companies are constantly marketing products in new ways that promise to activate new muscles and make you bigger and stronger than ever before. But do these supplements actually work?
3405 Posted 425 Days Ago in: Training, Genetics, Industry News, Nutrition
As part of my job role at DNAFit, I read a lot of different scientific papers from a wide range of disciplines within sports science. At the end of 2015, I reviewed the best bits of research I had come across in 2015 (click for Part One and Part Two), and in this two-part article I will share with you the papers that had the biggest impact on me in 2016.
3391 Posted 472 Days Ago in: Training, Genetics, Nutrition
When running customers through their DNAFit reports, a common question I am asked is â€śAre my results normal?â€ť This is a tough question to answer, because itâ€™s hard to define what normal actually is. For all the single nucleotide polymorphisms (SNPs) we test for, each individual genotype is quite common; the least common genotype occurs in about one in twenty people, which means that in the UK over three million people who have that specific version.
3387 Posted 481 Days Ago in: Genetics, Nutrition
This week we are investigating ADRB3, a gene which appears in our fat sensitivity panel. This gene encodes for beta-3-adrenergic receptors, which are located mainly is fat tissue. They play a role in breaking down fat for use as energy, and a small change in this gene, known as a single nucleotide polymorphism (SNP), is thought to determine how well we can tolerate saturated fats.
3382 Posted 495 Days Ago in: Training, Genetics
This week to turn our attention to PPARGC1A, or as we call it at DNAFit, â€śthe one with the long nameâ€ť. This gene encodes for a protein called peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), which causes some of the positive changes that occur in our body following exercise. One of the ways that exercise can lead to improvements is through something called mitochondrial biogenesis, which is the production of new mitochondria within the muscle itself.
3377 Posted 509 Days Ago in: Genetics, Nutrition
This week we turn our attention to FABP2, a gene that appears in both the carbohydrate and saturated fat parts of our reports. This gene creates a protein called Fatty Acid Binding Protein-2, which is found in our small intestines. FABP2 binds to the various different fatty acids, and allows them to be absorbed into the body.
3375 Posted 515 Days Ago in: Training
We know how you feelâ€¦ Youâ€™re older and have never really committed to training, or you may feel as though the prospect of getting in the gym or running on the road is too daunting â€“ thatâ€™s it too late. Itâ€™s not. Although it may seem as though starting now may do more harm than good, itâ€™s actually pretty much the opposite.
3373 Posted 519 Days Ago in: Training, Genetics
There are pros and cons as you get older, and a little more decline if youâ€™re into training, but there are also interventions that you can make to adapt to changes and maintain a lifestyle of efficiency long into what is perceived as old age. First, weâ€™ll take you through the changes that occur when you get older:
3367 Posted 537 Days Ago in: Genetics
Our attention this week is on another gene that is found as part of our Peak Performance algorithm, which has been shown to enhance response to a resistance training programme. The gene we are focusing on this week is BDKRB2, which encodes for the bradykinin B2 receptor, which comprises one of the pathways through which bradykinin can exert its influence. Bradykinin itself is a protein that causes dilation (widening) of blood vessels, making it easier for blood to move to certain areas of the body. The effects of this gene are closely linked to the of ACE, which is a gene we met earlier in this series. Angiotensin-Converting Enzyme, which is produced by the ACE gene, also breaks down bradykinin, such that ACE II genotypes (who have lower levels of ACE) should theoretically have higher levels of bradykinin.
3359 Posted 558 Days Ago in: Genetics
If youâ€™ve ever heard that a glass of red wine per day is good for your heart, this is truer for some people than others. Plenty of research has shown that moderate amounts of alcohol consumption can protect against risks of heart disease. For example, a study published in 1997 found that alcohol intake was associated with a protective effect against coronary heart disease in a sample of almost 130,000 people â€“ this effect was present for both beer and wine. A second study, again from 1997, found that in both men and women, rates of cardiovascular disease were 30-40% lower in those consuming at least one drink per day compared to abstainers.
3358 Posted 561 Days Ago in: Training, Genetics
Amongst all the records, achievements and scandals at Rio 2016, a small piece of history was written. Leila, Liina and Lily Luik from Estonia became the first identical triplets to compete against each other in a single event â€“ the marathon. If this wasnâ€™t proof enough that athletic talent runs in the family, there were at least 36 sets of siblings competing in the Rio Olympics, showcasing family dominance at the Summer Games.
3356 Posted 565 Days Ago in: Training, Genetics
In this week's edition of our blog, we look at PPARA, a gene that affects how well we can respond to different types of training, and as a result appears in our power-endurance algorithm. PPARA creates peroxisome proliferator-activated receptor alpha, a protein which activates other genes, as well as being a regulator of fatty acid oxidation during exercise. The gene is activated when our cells arenâ€™t getting enough energy, such as when we fast, or when we take part in exercise that uses up our energy stores, such as endurance exercise.
3354 Posted 570 Days Ago in: Genetics
When we think of calorie counting we think of reducing the amount of food you eat every single meal, carefully measuring it on a mental scale and extending lunch breaks spent analysing how many calories every single item of food you aim to consume. When you look at it this way, itâ€™s a very stressful experience. But it doesnâ€™t have to be. Thereâ€™s always more than one way to skin a cat, or, in this case, trim the fat.
3353 Posted 572 Days Ago in: Training, Genetics
This week, we look at a gene that plays a role in both the power/endurance and aerobic trainability aspect of our report. This gene is VEGF, and it creates Vascular Endothelial Growth Factor, which plays a role in the creation of new blood vessels. This is a useful adaptation to aerobic training, because more blood vessels around the muscle mean better, more efficient transport of oxygen, as well as fuel sources such as carbohydrates and fats, to the muscle; this in turn improves how well a person can use oxygen and exercise aerobically. When we exercise, our muscle cells quite often donâ€™t get as much oxygen as they need. This causes the VEGF gene to be â€śturned onâ€ť, with transcription upregulated and more VEGF formed â€“ leading to this increased growth of new blood vessels.
3349 Posted 582 Days Ago in: Training, Genetics
Whatever your fitness goal is, we all get discouraged when a heavy training regime brings us no or very little effect, especially if we canâ€™t figure out why. Well, fear no more because DNAFit are here to bring you some mistakes that you may be making in the gym that are the reasons why your muscle building exercises arenâ€™t working at their optimum level.
3341 Posted 590 Days Ago in: Training, Genetics
Everyone around the world is getting sport fever. The Olympics are back! Here at DNAFit weâ€™ve done a little investigation into what role stress plays in athletic performance during the Olympics, and how the worldâ€™s top athletes deal with pressure to still go for the gold in their quest to be the best. Weâ€™ve drawn from a variety of theories to paint you a comprehensive picture of the complicated relationship between athletic performance and stress and the different ways in which it manifests.
3339 Posted 592 Days Ago in: Genetics
SOD2 is the gene that creates Manganese Superoxide Dismutase-2 (MnSOD2), an antioxidant found in the mitochondria â€“ small â€ścells within our cellsâ€ť which are where our body produces energy for both movement and everyday life. The enzyme helps to convert free radicals, which can cause damage to the mitochondria, into oxygen and hydrogen peroxide.
3337 Posted 598 Days Ago in: Genetics
In this series, weâ€™ll be providing insight into the limitations some of us have concerning food and what this means in terms of our genes. This will hopefully provide more clarity, aiding you to understand why, for instance, some people are predisposed to coeliac disease or are lactose intolerant, while giving you solutions to overcoming these issues and leading a healthy lifestyle. This week weâ€™re investigating the history, prevalence, reasons and solutions to dealing with lactase non-persistence, popularly known as lactose intolerance, which affects about 65% of the population. The infographic concisely explains how it all started and the role it plays in the daily lives of people today; offering deep insight into a concept that at first seems simple but is dense with information and presents a compelling view of our history and evolution.
3335 Posted 603 Days Ago in: Training, Genetics
We tasked our DNAFit sports scientist with giving us insight into what athletes do in terms of their fitness and nutrition in order to stay at the highest level and always be on top of their game. Below youâ€™ll find helpful tips and tricks to implement into your own daily life regarding what you eat and how you exercise, so that you too can reach peak performance and fulfil your fitness potential.
3334 Posted 606 Days Ago in: Training, Genetics
Continuing our focus on specific genes, this week we place FTO under the microscope. This gene plays a role in determining how well we deal with fats, especially saturated fats, but it is also implicated in obesity risk â€“ as such, FTO is called the fat mass and obesity-associated gene.
3331 Posted 614 Days Ago in: Training, Genetics
The next gene to be put under our spotlight is CRP. This gene affects both the aerobic trainability and recovery aspects of our report, as well as playing a role in the DNAFit Peak Performance algorithm. Small changes within this gene cause changes in the amount of CRP we would expect each person to have, both at baseline and following exercise. CRP stands for C-Reactive Protein, which is a marker for inflammation.
3329 Posted 624 Days Ago in: Training, Genetics
GDF-5 is a gene which encodes for a protein called Growth Differentiation Factor-5. Whilst the specific role of this protein is currently unknown, we do know that a SNP contained within the gene is associated with an increased injury risk, especially with regards to tendons, ligaments, and bone.
3327 Posted 632 Days Ago in: Training, Genetics
Weâ€™ve all heard the word â€śantioxidantâ€ť but what does it even mean? Antioxidants are the front line in defense when it comes to combating free radicals that contribute to cell damage. They neutralize the effects of these free radicals, which are produced by your body, and reduce oxidative damage, which has been linked to degenerative diseases. But are antioxidants important when training?
3326 Posted 633 Days Ago in: Genetics
At the end of last year a study was conducted on people by Eran Segal and Eran Elinav of the Weizmann Institute of Science that confirmed what we at DNAFit already know; there is no one-size-fits-all approach to dieting and weight loss.
3324 Posted 640 Days Ago in: Genetics
The gene that we are going to be taking a closer look at this week is TCF7L2. This gene creates a protein called transcription factor 7-like 2, which in turn binds to other genes to alter their expression. It has been shown through research to have an impact on how well you tolerate carbohydrates, and how well you tolerate saturated fat, which is how we report on it in the DNAFit reports.
3322 Posted 631 Days Ago in: Training, Genetics
Do you struggle too find the right training method for your goals? You've probably come across all sorts of different advice offering the new best workout that will change everything. Every fitness craze effectively prescribes a one-size-fits-all approach for you to achieve your #FitnessGoals. What works for one is often less effective for another - that's because we're all different, and so is the way we respond to training.
3321 Posted 648 Days Ago in: Genetics
This week we are going to be looking at a gene that affects how well we can tolerate lactose. Roughly 65% of the worldâ€™s population lose the ability to digest lactose, the sugar found in milk, after weaning. From an evolutionary perspective, this makes sense â€“ humans typically need to digest milk when they are babies because their main source of nutrition is breast milk; however, once the child has stopped breast feeding, historically there was no need for them to continue to digest lactose, because milk wasnâ€™t readily available. However, as humans migrated out of Africa into Asia, and eventually into Europe, a small polymorphism occurred which enabled some of them to continue to digest lactose into adulthood.
3317 Posted 662 Days Ago in: Training, Genetics
The next gene in our series is perhaps one of the more controversial ones; MTHFR. This gene creates an enzyme with an incredibly long name â€“ Methylene tetrahydrofolate reductase. This enzyme is part of a complex chemical pathway known as the methyl cycle, which plays a role in the conversion of a potentially harmful compound called homocysteine, into a safe amino acid, called methionine.
3313 Posted 670 Days Ago in: Genetics
In this edition of Gene in Focus, we are going to look at a gene that effects our saturated fat sensitivity, called ApoA2. This gene creates Apolipoprotein A-II, which is part of high density lipoproteins (HDL). A small change in this gene can have an effect on how well you can transport cholesterol, and the research also indicates that it can have an impact on how well you can tolerate saturated fat.
3310 Posted 677 Days Ago in: Training, Genetics, Industry News
The idea behind the research was to validate the algorithm DNAFit use to determine the best type of training for each person. We all know intuitively that we respond different to the same training; if youâ€™ve ever had a training partner Iâ€™m sure its fair to say that you both did not see exactly the same improvements. The difference in improvements between individuals is partly genetic, and research in recent years has focused on identifying genes that can play a role in training response.
3307 Posted 684 Days Ago in: Training, Genetics
The next gene we are going to discuss in the focus series is ACTN3. Itâ€™s one of the most well studied genes with regards to sporting performance. ACTN3 codes for a protein that is found exclusively in the fastest kind of muscle fibres, type IIx, called a-actinin-3. Fast twitch muscle fibers can contract quickly and powerfully, and as such are linked to sprinting or weightlifting. Generally, people who are quick or strong will have plenty of type-IIx muscle fibers, whilst people who are better at long distance running will have more type-I muscle fibers (often called slow twitch muscle fibers).
3305 Posted 689 Days Ago in: Training, Genetics
For many years a diet that was low in fat was recommended as the perfect way to stay slim and maintain a healthy heart. Recently there has been a cultural move towards increasing healthy fats and cutting carbs but for many people their DNA may be better suited to keeping dietary fat low.
3304 Posted 690 Days Ago in: Training, Genetics
The next gene in this series is another one that appears in two separate sections â€“ COL5A1. This gene can have an effect on endurance performance and also injury risk; but the allele that increases injury risk also improves endurance performance; one of natureâ€™s cruel jokes.
3302 Posted 696 Days Ago in: Genetics
We all need vital vitamins and minerals. But for some people, differences in their DNA means they are less able to absorb or use specific micronutrients. If thatâ€™s you, the good news is that by changing your diet, you can boost your levels, stay healthy and protect yourself from deficiency and disease.
3301 Posted 698 Days Ago in: Training, Genetics
As part of a new series on the DNAFit blog, we are going to look at a specific gene in detail, see what the science says about it, and how it can affect you with regards to fitness and diet. The first gene to be put under the microscope in our series is ACE, or the angiotensin-converting enzyme gene. Did you know that knowing your ACE genotype can empower you to make better decisions regarding your training and also your diet?
3298 Posted 703 Days Ago in: Genetics, Nutrition
Examining your DNA can help you discover the diet plan that is perfect for your individual genetic structure. In studies, this personalized approach to nutrition was shown to be more effective than traditional diet methods. By eating for our unique dietary needs itâ€™s easier to make long-term sustainable changes to improve our health and wellbeing. This week we're giving you an overview on different types on most-common recommended diets.
3297 Posted 704 Days Ago in: Genetics
The new and developing science of Nutrigenetics aims to identify genetic susceptibility to diseases and the ways in which very small difference in our genes can alter the effects that nutrient intake has on the body. By understanding and analysing these variations, specific dietary and disease prevention advice can be given based on personal genetic makeup.
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